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Bio-Techne corporation
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Image Search Results
Journal: Journal of Biomedical Science
Article Title: Decoy receptor 3: an endogenous immunomodulator in cancer growth and inflammatory reactions
doi: 10.1186/s12929-017-0347-7
Figure Lengend Snippet: Mechanisms of DcR3.Fc-mediated immunomodulation. a DcR3 modulates the activation and differentiation of myeloid cells via HSPGs. DcR3.Fc triggers downstream signaling via syndecan-2 and CD44v3 on monocytes to influence monocyte differentiation into dendritic cells (DCs) and macrophages (Mϕ). DcR3-treated DC skews allogenic T cell differentiation into Th2 phenotype, while DcR3-treated Mϕ displays typical M2 markers, and is able to enhance tumor growth and tissue repairing. b DcR3 modulates B cell activation via a yet-identified ligand on B cells. DcR3.Fc suppresses TLR2 ligand (Pam3CSK4) and Staphylococcus aureus cowan (SAC) strain-induced B cell activation via binding non-HSPG ligand(s) on B cells
Article Snippet: The discrepancy may due to the different composition of recombinant DcR3.Fc proteins, as the
Techniques: Activation Assay, Cell Differentiation, Binding Assay
Journal: Journal of Biomedical Science
Article Title: Decoy receptor 3: an endogenous immunomodulator in cancer growth and inflammatory reactions
doi: 10.1186/s12929-017-0347-7
Figure Lengend Snippet: Autocrine loop of DcR3-mediated immunomodulation. Endogenous DcR3 is induced in cancer cells or keratinocytes by various stimuli, including UV, sex hormone, viruses, and cytokines. Endogenous DcR3 enhances tumor migration, metastasis, growth, and resistance to chemotoxicity in tumor cells. DcR3 is also upregulated in psoriatic lesions and impairs keratinocyte differentiation. Aberrant expression of DcR3 and DcR3 variants are observed in rheumatoid arthritis (RA), inflammatory bowel disease (IBD), multiple sclerosis (MS), systemic lupus erythematosus (SLE), and asthma
Article Snippet: The discrepancy may due to the different composition of recombinant DcR3.Fc proteins, as the
Techniques: Migration, Expressing